4-Chloro-2-((1R)-1-{[(R)-(2-chlorophenyl)(cyclopentyl)methyl]amino}ethyl)phenol
نویسندگان
چکیده
The title compound, C(20)H(23)Cl(2)NO, was prepared by condensation of (R)-1-(2-chloro-phen-yl)-1-cyclo-pentyl-methanamine with 1-(5-chloro-2-hydroxy-phen-yl)ethanone, resulting in the formation of a new chiral center. The structural analysis confirms the absolute configuration of the title compound and the formation of the (R,R) diastereoisomer. There is an intra-molecular O-H⋯N hydrogen bond which stabilizes the conformation of the mol-ecule. The mol-ecules are linked to each other through weak C-H⋯π inter-actions.
منابع مشابه
2,4-Dichloro-6-((1R)-1-{[(R)-(2-chlorophenyl)(cyclopentyl)methyl]amino}ethyl)phenol
In the title compound, C(20)H(22)Cl(3)NO, the five-membered ring adopts an envelope conformation, and the two benzene rings are oriented at a dihedral angle of 40.44 (9)°. Intra-molecular O-H⋯N and N-H⋯Cl hydrogen bonding is present. In the crystal, the mol-ecules are linked via weak inter-molecular C-H⋯O hydrogen bonds.
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In the title compound, C(21)H(25)Cl(2)NO, the dihedral angle between the two benzene rings is 33.18 (11)°. The five-membered ring adopts an envelope conformation. There is an intra-molecular O-H⋯N hydrogen bond. In the crystal, mol-ecules are linked by weak N-H⋯Cl hydrogen bonds, forming a helical chain along the c axis.
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